___

• 1. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58:26-35.
• 2. Felson DT. Clinical practice. Osteoarthritis of the knee. N Engl J Med. 2006;354:841-8.
• 3. Felson DT, Lawrence RC, Hochberg MC, McAlindon T, Dieppe PA, Minor MA et al. Osteoarthritis: new insights. Part 2: treatment approaches. Ann Intern Med. 2000;133:726-37.
• 4. Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2010;18:24-33.
• 5. Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol. 2012;8:729-37.
• 6. Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12:580-92.
• 7. Kuyumcu ME, Yesil Y, Oztürk ZA, Kizilarslanoğlu C, Etgül S, Halil M et al. The evaluation of neutrophil-lymphocyte ratio in Alzheimer's disease. Dement Geriatr Cogn Disord. 2012;34:69-74.
• 8. Boyraz I, Koç B, Boyacı A, Tutoğlu A, Sarman H, Ozkan H. Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF. Int J Clin Exp Med. 2014;7:2912-15.
• 9. Kilincalp S, Çoban Ş, Akinci H, Hamamcı M, Karaahmet F, Coşkun Y et al. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma. Eur J Cancer Prev. 2015;24:328-33.
• 10. Kellgren JH, Lawrance JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16:494-502.
• 11. Akopuz A, Turan V, Ozcan A, Kopuz Y, Toz E, Kurt S. A novel marker for the assessment of the treatment result in pelvic inflammatory disease. Minerva Ginecol. 2016;68:117-23.
• 12. Botta C, Barbieri V, Ciliberto D, Rossi A, Rocco D, Addeo R et al. Systemic inflammatory status at baseline predicts bevacizumab benefit in advanced non-small cell lung cancer patients. Cancer Biol Ther. 2013;14:469-75.
• 13. Correale P, Tagliaferri P, Fioravanti A, Del Vecchio MT, Remondo C, Montagnani F et al. Immunity feedback and clinical outcome in colon cancer patients undergoing chemoimmunotherapy with gemcitabine + FOLFOX followed by subcutaneous granulocyte macrophage colony-stimulating factor and aldesleukin (GOLFIG-1 Trial). Clin Cancer Res. 2008;14:4192–9.
• 14. Lissoni P, Brivio F, Fumagalli L, Messina G, Ghezzi V, Frontini L et al. Efficacy of cancer chemotherapy in relation to the pretreatment number of lymphocytes in patients with metastatic solid tumors. Int J Biol Markers. 2004;19:135-40.
• 15. Taşoğlu Ö, Bölük H, Onat Ş, Taşoğlu İ, Özgirgin N. Is blood neutrophil-lymphocyte ratio an independent predictor of knee osteoarthritis severity Clin Rheumatol. 2016;35:1579-83.
• 16. Liu H, Wu Y, Wang Z, Yao Y, Chen F, Zhang H et al. Pre treatment platelet-to-lymphocyte ratio (PLR) as a predictor of response to first-line platinum-based chemotherapy and prognosis for patients with nonsmall cell lung cancer. J Thorac Dis. 2013;5:783-9.
• 17. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436-44.
• 18. Matowicka-Karna J, Kamocki Z, Polińska B, Osada J, Kemona H. Platelets and inflammatory markers in patients with gastric cancer. Clin Dev Immunol. 2013;2013:401623.
• 19. Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol. 2002;118:787-93.
• 20. Yazici S, Yazici M, Erer B, Erer B, Calik Y, Bulur S et al. The platelet functions in patients with ankylosing spondylitis: anti-TNF-alpha therapy decreases the mean platelet volume and platelet mass. Platelets. 2010;21:126-31.
• 21. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008;75:291-4.
• 22. Şahin A, Yetişgin A, Şahin M, Durmaz Y, Cengiz AK. Can Mean Platelet volume be a surrogate marker of inflammation in rheumatic diseases? West Indian Med J. 2015;65:165-9.
• 23. Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets. 2014;25:81-526.
• 24. Martin JF, Bath PMW. Platelets and megakaryocytes in vascular disease. In: Antithrombotics: Pathophysiological Rationale for Pharmacological Inventions (Ed AG Herman):49-62. Dordrecht, Boston, Kluwer Academic Publishers, 1991.
• 25. Sharp DS, Benowitz NL, Bath PM, Martin JF, Beswick AD, Elwood PC. Cigarette smoking sensitizes and desensitizes impedance-measured ADP-induced platelet aggregation in whole blood. Thromb Haemost. 1995;74:730-5.
• 26. Schmitt-Sody M, Metz P, Gottschalk O, Birkenmaier C, ZyskS, Veihelmann A et al. Platelet P-selectin is significantly involved in leukocyte-endothelial cell interaction in murine antigen-induced arthritis. Platelets. 2007;18:365-72.
• 27. Schmitt-Sody M, Metz P, Klose A, Gottschalk O, Zysk S, Hausdorf J et al. In vivo interactions of platelets and leucocytes with the endothelium in murine antigeninduced arthritis: The role of P-selectin. Scand J Rheumatol. 2007;36:311-9.
• 28. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157-61.
• 29. Calabro P, Chang DW, Willerson JT, Yeh ET. Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol. 2005;46:1112–3.
• 30. Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis. 2013;5:77-94.
• 31. Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005;64:1263-7.
• 32. Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum. 2001;44:1237-47.
• 33. Pearle AD, Scanzello CR, George S, Mandl LA, DiCarlo EF, Peterson M et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage. 2007;15:516-23.
• 34. Fernandez-Madrid F, Karvonen RL, Teitge RA, Miller PR, An T, Negendank WG. Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis. Magn Reson Imaging. 1995;13:177-83.
• 35. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol. 2010;6:625-35.
• 36. Hussein MR, Fathi NA, El-Din AME, Hassan HI, Abdullah F, AlHakeem E et al. Alterations of the CD4(þ), CD8 (þ) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis facto ralpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations. Pathol Oncol Res. 2008;14:321e8.
• 37. Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol 2012;8:390e8.
• 38. Haywood L, McWilliams DF, Pearson CI, Gill SE, GanesanA, Wilson D et al. Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum 2003;48:2173e7.
• 39. Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, LaheyLJ et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther. 2012;14:R7
• 40. Attur M, Statnikov A, Aliferis CF, Li Z, Krasnokutsky S, Samuels J et al. Inflammatory genomic and plasma biomarkers predict progression of symptomatic knee OA (SKOA). Osteoarthritis Cartilage. 2015;23:1915-24.
• 41. Fernández-Puente P, Mateos J, Fernández-Costa C, OreiroN,Fernández-López C, Ruiz-Romero C et al. Identification of a panel of novel serum osteoarthritis biomarkers. J Proteome Res. 2011;10:5095-101.
• 42. Revell PA, Mayston V, Lalor P, Mapp P. The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann Rheum Dis. 1988;47:300-7.
• 43. Furuzawa-Carballeda J, Macip-Rodriguez PM, Cabral AR. Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. Clin Exp Rheumatol. 2008;26:554–60.
• 44. Ross TN, Kisiday JD, Hess T, McIlwraith CW. Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide. Osteoarthritis Cartilage. 2012;20:1583-90. 336