Berna Bozkurt DUMAN, Oğuz İsmail KARA, Eren ERKEN

Behçet Hastalığı ve Kanser İlişkisi: Retrospektif Analiz Tek Merkez Deneyimi

Amaç: Behçet Hastalığı vaskülitik bir hastalıktır. Behçet Hastalığı ile kanser birlikteliği çok sık değildir. Biz çalışmamızda Behçet Hastalığı kanser ilşkisini araştırdık. Hastalar ve Yöntem: 2005-2010 yılları arasında takip edilmiş 105 Behçet Hastası ça lışmaya alındı. Histopatolojik olarak konfirme edilmiş malignensisi olan hastalar belirlendi. Bulgular: Bu takip süresinde klavuzlara uygun olarak düzenli taramaları yapılan hastalardan sadece birinde malignensi gözlendi. Bu hasta 55 yaşında meme kanseri tanısı aldı ve 16 yıl kolşisin kullanımı mevcuttu. Meme kanserine yönelik olarak modifiye radikal mastektomi ve 4 kür doksorubisin; siklofosfamid kombinasyonu uygulandıktan sonra tedaviye Tamoksifen ve LHRH anologu ile devam edildi. Sonuç: Bazı romatolojik hastalıklar kanser gelişimine predispozisyon yaratabilir. Hastalığın natürü ve kullanılan immunsupresif ilaçlar bundan sorumlu olabilir. Bizim çalışmamızda direk böyle bir ilişki gösterilemedi. Ama diğer bir yandan önemle vurgulanması gereken Behçet Hastalığı ile malignensi birlikteliğinde her 2 hastalığın birlikte dikkatlice yönetimidir.

Anahtar Kelimeler:

Behçet Hastalığı, kanser, meme

Retrospective Analysis of Cancer with Behcet"s Disease: Single Center Experience

Purpose: Behçet"s disease (BD) is a vasculitis of unknown origin. In autoimmune and vasculitic disorders the risk of malignancies has been extensively studied. In BD patients more than hundred cases associated with malignancies have been published. However, the direct relationship with BD has not been proved. We aimed to to investigate the incidence of malignancies in BD patients Material and Methods: Here in we assessed 105 cases retrospectively between 2005-2010 with BD diagnosed according to International Study Criteria (ISG) . The patient"s data were reviewed for development of histopathologically confirmed malignancy Results: One of our 105 patients with BD was found to have solid tumor in the rate of 0.9 %. The remaining 104 patients with BD were in follow up without any malignancy in this period. The malignancy that we reported was invasive right breast carcinoma in a 55-year-old woman with BD. A radically modified right mastectomy and axillary lymphadenectomy were performed and postoperative doxorubicin, cyclophosphamide therapy for four cycles and hormonal therapy with tamoxifen and leuprolide acetate was administered as adjuvant therapy. This patient had a history of 16 years colchicine usage as medication for BD. Conclusion:The rheumatologic diseases can predispose malignancy, the autoimmune nature of BD or the immunosupressive medicines could be possible causes of this carcinoma. However, in our study only one patient had malignancy. The another point of view; management and also prevention of cancer with BD is important entity.

Keywords:

Behcet"s disease, cancer, breast,

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Yazışma Adresi / Address for Correspondence: Dr. Berna Bozkurt Duman Çukurova University Medical Faculty, Department of Oncology, 01330 Balcalı / ADANA e mail: berboz@hotmail.com geliş tarihi/received :27.09.2013 kabul tarihi/accepted:14.10.2013