Zeynep KARAKAYA, Pınar Yeşim AKYOL, Firdes TOPAL, Fatih ESAD, Mehmet Coşkun AYKAÇ

Akut pankreatitte prokalsitonin düzeyinin mortalite üzerine etkisi

Amaç: Bu çalışmanın amacı başvuru ve 48. saatte alınan prokalsitonin seviyesinin mortalite ve yatış süresi üzerine etkisinin araştırılmasıdır. Gereç ve Yöntem: Kesitsel retrospektif olan çalışmamızda 3 ay içerisinde acil servise başvuran ve pankreatit tanısı ile servise yatırılan hastalar çalışmaya alındı. Çalışmaya dahil edilen tüm hastaların yaş, cinsiyet, kronik hastalık varlığı, alkol alımı, taş varlığı, ranson geliş değeri, ranson 48. saat değeri, bilgisayarlı tomografi şiddet indeksi, lökosit, platelet, lenfosit, nötrofil sayıları, nötrofil lenfosit oranları, platelet lenfosit oranları, C-Reaktif Protein, Prokalsitonin 0.saat, Prokalsitonin 48.saat düzeyleri ve bunların 6 aylık mortalite ve morbidite üzerine etkisi değerlendirildi. Bulgular: Çalışmaya alınan 39 hastanın %48.7 si (n=19)’u erkek %51.3’ü (n=20) kadındı. Pankreatit tanısı alan hastalardan %10.3 hastada (n=4) alkol kullanımı, %53.8 hastada(n=21) taş varlığı tesbit edildi. Olguların yatış süreleri ile C-Reaktif Protein değerleri arasında pozitif yönde ve istatistiksel olarak anlamlı korelasyon bulundu. 6 aylık mortalite (+) olguların Ranson 48. Saat değerleri 6 aylık mortalite (-) olguların Ranson 48. saat değerlerinden istatistiksel olarak anlamlı yüksek bulundu. Prokalsitonin başvuru esnasında, Prokalsitonin 48.saat düzeyleri ve bunların 6 aylık mortalite ve yatış süreleri üzerine istatistiksel anlamlı etkisi bulunmadı. Sonuç: Pankreatit tanılı hastalarda acil serviste C-Reaktif Protein değerlerine bakılması yatış süresinin tahmininde kullanılabilir. Prokalsitonin başvuru esnasında ve 48. saat değerleri acil serviste yatış süresi ve mortalitenin değerlendirilmesinde kullanımı uygun değildir. Ranson 48. Saat değerlendirmesi mortalite tahmininde kullanılabilir.

Anahtar Kelimeler:

Pankreatit, prokalsitonin, mortalite

Effect of procalcitonin level on mortality in acute pancreatitis

Purpose: The aim of this study was to investigate the effect of procalcitonin level at application time and 48th hour on the mortality and the length of stay in this study. Materials and Methods: In our cross-sectional retrospective study. patients who applied for emergency services within 3 months and were hospitalized with a diagnosis of pancreatitis were included in the study. CRP. Procalcitonin levels at application time and 48th h, Computed Tomography Severity Index, Leukocyte, platelet, lymphocyte, neutrophil counts. Neutrophil lymphocyte ratio, platelet lymphocyte ratio values, age, gender, presence of chronic illness, alcohol intake, stone existence, ranson value of all patients included in the study that we appraised affect on mortality and morbidity in 6 months. Results: 48 patients (n = 19) and 51.3% (n = 20) of 39 patients were included in the study. Alcohol use was found in 10.3% of patients (n = 4) and stone presence was found in 53.8% (n = 21) of patients who were diagnosed as pancreatitis. Positive and statistically significant correlations were found between admission duration and C-reactive protein values. Ranson 48th hour values of 6 month mortality (+) were statistically higher than Ranson 48th hour values of 6 month mortality (-). There was no statistically significant effect of procalcitonin on admision procalcitonin 48th h levels and their 6-month mortality and length of stay. Conclusion: In pancreatitis patients. C-reactive protein values in emergency patients can be used to estimate the duration of hospitalization. The on admision and 48th h values of procalcitonin are not suitable for the evaluation of the duration of emergency servitude and mortality. Ranson 48th h time evaluation can be used in predicting mortality.

Keywords:

Pancreatitis Procalcitonin, mortality, Emergency Room,

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