SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION
In this study, the
emergences of postsynaptic action potentials are investigated using simulation
study which is depended on the statistical model of acetylcholine (Ach) quantal
release theory at motor end-plate. It is supposed that the end-plate potentials
(EPP) are sum of miniature end-plate potentials (MEPP) which are released as
quantal and random in number (N). By the hypothesis that N number has a Poisson
and MEPPs have a Gaussian distribution, EPPs
are obtained by simulating distributions parameters. Our study suggests that
the simulation of the EPPs are a
convenient tool in understanding both
physiological process of synaptic transmission
and pathological process of neuromuscular junction.
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