YENİ OKSAZOLİDİNONLARIN ANTİMİKROBİYAL AKTİVİTELERİNİ DEĞERLENDİREN BİR ARAŞTIRMA

Amaç: Bu çalışmada, bazı yeni oksazolidinon türevlerinin antimikrobiyal etkileri S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, metisilin-dirençli Staphylococcus aureus (MRSA) klinik izolatı ve C. albicans ATCC 10231’e karşı incelenmiştir.Gereç ve Yöntem: Daha önce elde edilen ve yayınlanan 10 oksazolidinonların antimikrobiyal aktivitesi test edilmiştir ve çalışma Mueller-Hinton broth ve Sabouraud dekstroz broth içinde gerçekleştirilmiştir.Sonuç ve Tartışma: E5 ve E9 bileşikleri, sırasıyla, 25 μg/mL ve 50 μg/mL ile hem bakteri hem de mantarlara karşı antimikrobiyal aktivite göstermiştir. Bizim bu araştırmamız ve diğer bazı çalışmalar, elektro-negatiflik derecesinin biyolojik aktivite için çok önemli olduğunu göstermiştir.

A RESEARCH FOR SOME OXAZOLIDINONES TO EVALUATE THEIR ANTIMICROBIAL ACTIVITY

Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231.

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