YENİ N'-SÜBSTİTÜE-2-((5-(TİYOFEN-2-İLMETİL)-4H-1,2,4-TRİAZOL-3-İL)TİYO) ASETOHİDRAZİTLERİN SENTEZ YÖNTEMİ

Amaç: Bu çalışmanın amacı, bir seri yeni N'-sübstitüe-2-((5-(tiyofen-2-ilmetil)-4H-1,2,4-triazol-3-il)tiyo)asetohidrazit sentezlemektir.

METHOD OF SYNTHESIS NOVEL N'-SUBSTITUTED- 2-((5-(THIOPHEN-2-YLMETHYL)-4H-1,2,4-TRIAZOL-3-YL)THIO) ACETOHYDRAZIDES

Objective: The purpose of this work is to synthesize new series of N'-substituted-2-((5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides.

___

Pattan, S., Gadhave, P., Tambe, V., Dengale, S., Thakur, D., Hiremath, S. V., & Deotarse, P. (2012). Synthesis and evaluation of some novel 1, 2, 4-triazole derivatives for antmicrobial, antitubercular and anti-inflammatory activities. Indian Journal of Chemistry Section B 51(1):297-301.

Chen, W., Su, H., Xu, Y., Jin, C. Scientific Reports. 2017.; 7:405–414.

Rodionova N., Manukovskaya M., Kolomnikova Ya. et. al. Vestnik Voronezhskogo gosudarstvennogo universiteta inzhenernyih tehnologiy. 2015.; Vol. 66, Iss. 4: 98–103.

Shcherbyna R.O. Farmatsevtychnyi chasopys. 2014.; 4: 145–150.

Aksonova I. I., Shcherbyna R. O., Panasenko O. I. et. al. Ukrainskyi biofarmatsevtychnyi zhurnal. 2014.; 6: 78–82.

Cervantes-Elizarrarás, A., Piloni-Martini, J., Ramírez-Moreno, E., Alanís-García, E., Güemes-Vera, N., Gómez-Aldapa, C. A., del Socorro Cruz-Cansino, N. Ultrasonics Sonochemistry. 2017; Vol. 34: 371–379.

Thakkar, S. S., Thakor, P., Doshi, H., & Ray, A. (2017). 1,2,4-triazole and 1,3,4-oxadiazole analogues: synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. Bioorganic & Medicinal Chemistry. 25(15):4064-4075. doi: 10.1016/j.bmc.

Kumar, G. S., Prasad, Y. R., & Chandrashekar, S. M. (2013). Synthesis and pharmacological evaluation of novel 4-isopropylthiazole-4-phenyl-1, 2, 4-triazole derivatives as potential antimicrobial and antitubercular agents. Medicinal Chemistry Research, 22(2), 938-948.

Patel, N. B., Khan, I. H., Pannecouque, C., & De Clercq, E. (2013). Anti-HIV, antimycobacterial and antimicrobial studies of newly synthesized 1, 2, 4-triazole clubbed benzothiazoles. Medicinal Chemistry Research, 22(3), 1320-1329.

Rud, A. M., Kaplaushenko, A. G., Pruglo, Y. S., & Frolova, Y. S. (2018). Establishment Of Diuretic Activity Indicators For (3-Thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols And Their Derivatives. Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2018(2), 215-219.

Saidov, G., Sverdlova, O. and Bakhshiev, N. (1995). Prakticheskoe rukovodstvo po molekuli︠a︡rnoĭ spektroskopii. 1st ed. Sankt-Peterburg: Izd-vo Sankt-Peterburgskogo universiteta.

Kazitsena, L. and Kupletskaya, N. (1979). Primenenie UF-, IK-, YaMR - i MАSS - spectrometrii v orhanicheskoy khimii. 2nd ed. Moskow: University of Moscow, p.240.

Varynskyi, B., Knysh, Y., Parchenko, V., Panasenko, O., & Kaplaushenko, A. (2015). The study of retention regularities for the potential drug substances of 1,2,4-triazol-3-ylthioacetic acids and their salts series by the method of HPLC/DAD-MS. Journal Of Organic And Pharmaceutical Chemistry, 13(4), 68-75.

Tkachenko, A., Zazharsky, V., Bilan, M., & Kovaleva, L. (2010). Some peculiarities of bovis tuberculosis display in long not favourably farm. News of Dniproptrovsk State Agrarian and Economic University, (1), 100-103

Ankara Üniversitesi Eczacılık Fakültesi Dergisi-Cover
  • ISSN: 1015-3918
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2016
  • Yayıncı: Ankara Üniversitesi Eczacılık Fakültesi