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TEDAVİ ALTINDAKİ HİPERTANSİF HASTALARDA NONSTEROIDAL ANTİİNFLAMATUAR İLAÇLARIN ANTİHİPERTANSİF İLAÇLARLA ETKİLEŞMELERİ

Artrit ve hipertansiyon özelllikle yaşlılarda yaygın problemlerdir ve bunlar hastalarda sıklıkla birlikte bulunurlar. Bu nedenle artrit tedavisinde kullanılan nonsteroidal antiinflamatuvar ilaçlarla (NSAÎ1) birlikte antihipertansif ajanların kombine uygulanma potansiyeli bir hayli yüksektir. Pek çok NSAİİ; diüretikler, beta blokörler, anjiyotensin dönüştürücü enzim inhibitörleri gibi bazı antihipertansif ajanların hipotansif etkilerini azaltıcı potansiyele sahiptir. Bu antagonizmanın mekanizması öncelikli olarak prostanoidlerin oluşumunun NSAİİ'lar tarafından azaltılmasıyla ilgili görünmektedir. Bu çalışmanın amacı tedavi altındaki hipertansif hastalarda NSAİİ 'lar ve antihipertansifler arasındaki etkileşmeyi değerlendirmektedir

Anahtar Kelimeler:

Antihipertansif ilaçlar, Steroid olmayan antiinflamatuvar ilaçlar, Prostanoidler, Hipertansiyon

INTERACTIONS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS WITH ANTIHYPERTENSIVES IN TREATED HYPERTENSIVE PATIENTS

Arthritis and hypertension are both common problems in elderly persons and they co-exist frequently in patients. So the potential for concurrent administration of nonsteroidal anti-inflammatory drugs (NSAID s) used in treating arthritis together with antihypertensive agents is considerable. Most NSAID s have the potential to reduce the hypotensive effect of some antihypertensive agents such as diuretics, beta blockers, angiotensin converting enzyme inhibitors. The mechanism of this interaction seems primarily related to decrease in prostanoids formation by NSAID s. The aim of this study to evaluate the interaction of NSAID s and antihypertensives in treated hypertensive patients

Keywords:

Antihypertensive Drugs, Nonsteroidal Anti-inflammatory Drugs, Prostanoids, Hypertension.,

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1. Mark,C, Houston, M.D., "Nonsteroidal Anti-inflammatory Drugs and Antihypertensives", Am. J. Med., 90: 42-46 (1991).
2. Roberts, D.G., Gerber, J.G., Barnes, S.S., Zerbe, G.O., Nies, A.S., "Sulindac is not Renal Sparing in Man", Clin. Pharmacol. Ther., 38: 258-265 (1985).
3. Waller, P.C., Ramsay, L.E., "Arthritis and Drug Therapy in the Hypertension Clinic", Biomed. Pharmacother., 42: 207-211 (1988)
4. Houston, M.C., Weir, M.., Gray, J., Ginsberg. D., "The Effects of Nonsteroidal Antiinflammatory Drugs on Blood Pressures of Patients with Hypertension Controlled by Verapamil", Arch-Intern. Med., 22: 155(10), 1049-54 (1995).
5. Oates, J.A., "Antagonism of Antihypertensive Drug Therapy by Non-steroidal Anti-inflammatory Drugs", Hypertension, 11 (Suppl):, 114-116 (1988).
6. Brown, J., Dollery, C, Valdes, G., "Interaction of NSAID's with Anti-hypertansive and Diuretic Agents", Am. J. Med., 81 (Suppl.2B): 43-57 (1986).
7. Miller, G., Prichard, J.G., "Current Issues in NSAİD Therapy", Primary Care, 17:589-601 (1990).
8. Pope, J.E., Anderson, J.J., Felson, D.T., "Meta-analysis of the Effects of NSAID s in Blood Pressure", Arch. Int. Med., 153 (477-84), (1993).
9. Wong, D.G., Lamki, L., Spence, J.D., Freeman, D., McDonald J.W.D., "Effect of Nonsteroidal Anti-inflammatory Drugs on Control of Hypertension by Beta-blockers and Diüretics", Lancet, 1: 997-1001 (1986).
10. Jhonson, A.G., Nguyen, T.V., Day, R.O., "Do Nonsteroidal Antiinflammatory Drugs Affect Blood Pressure? A Metaanalysis", Ann. Intern. Med., 15: 121(4), 289-30 (1994).
11. Weiss, Y., Chenard, A., De-Kermadec, J.M., Tertrain, F., "Maintenance of Blood Control in Elderly Hypertensives on Ketoprofen" Scand. J.Rheumatol-Suppl., 91: 37-44 (1991).
12. Klassen, D.K., Jane, L.H., Young, D.Y., Peterson, C.A., "Assesment of Blood Pressure During Naproxen Therapy in Hypertensive Patients Treated with Nicardipine", Am. J. Hypertens., 8(2): 146-153 (1995).
13. Chamontin, B., Amar, J., "Drug Interactions with Antihypertensive Drugs", Therapie, 50(3): 221-226,(1995)
14. Dunn, M.J., "The Clinical Significance of Inhibition of Renal Prostaglandin Synthesis", Kidney Int., 32: 1-12(1987).
15. Murray, M.D., Brater, D.C., "Adverse effects of Nonsteroidal anti-inflammatory Drugs on Renal Function", Am. Int. Med., 112: 550-560 (1990).
16. Stillman, M.T., Schlesinger, P.A., "Nonsteroidal Anti-inflammatory Drug Nephrotoxicity", Arch. Intern. Med., 150: 268-270 (1990).
17. MacFarlane, L.L., Orak, D.J., Simpson, W.M., "NSAİDs, Anthypertensive Agents and Lo ss of Blood Pressure Control", Am. Fam. Physician, 51(4): 849-56 (1995).
18. Houston, M.C., "Nonsteroidal Anti-inflammatory Drugs and Antihypertensives", Am.J.Med., 90 (5A): 425-475 (1991).
19. Minuz, P., Barrow, S.E., Cockroft, J.R., Ritter, J.H., "Prostacyclin and Thromboxane Biosynthesis in Mild essential hypertension", Hypertension, 15: 469-74 (1990).
20. Kayaalp, O.S., 'Tıbbi Farmakoloji. 3. Cilt, 6. Baskı", Ankara Feryal Basımevi, 2959-2989, (1993).
21. Modebe, O., Eze, C.J., "Antagonism of Druğ Therapy for Hypertension by Nonsteroidal Antiinflammatory Drugs", West. Afr. J.Med., 12(1): 73-7 (1993).
22. Koopmans, P.P., "Effects of Indomethacin and Sulindac on Hydrochlorothiazide kinetics", Clin. Pharmacol. Ther., 37:625-28 (1985).
23. Magner, P., "Effects of Sulindac of Renal Prostaglandins and Glomerular Filtration Rate", Am. J. Med., 91 :206-208 (1991).
24. Minuz, P., Barrow, S.E., Cockcroft, J.R., Ritter, J.H., "Effects of NSAID s on Prostacyclin and Thromboxane Biosynthesis in Patients with Mild Essential Hypertension", Br. J. Clin. Pharmac, 30:519-526(1990).
25. Webster, J., "Interactions of NSAID's with Diuretics and blockers Mechanisms and Clinical Implications", Drugs, 30: 32-41 (1985).
26. Mene, P., Pughese, F., Patrono, C, "The Effects of Nonsteroidal Anti-inflammatory Drugs on Human hypertensive Vascular Disease", Semin. Nephrol., 15(3): 244-52 (1995).
27. Leeuw, P,W., "Nonsteroidal Antiinflammatory Drugs and Hypertension", Drugs 51(2): 179-187, (1996).
28. Kayaalp, O.S., "Tıbbi Farmakoloji. 2. Cilt, 7. Baskı", Ankara Feryal Basımevi, 1115-1197 (1995).
29. Jeffrey, S., Stoff, M.D., "Prostaglandins and Hypertension", Am. J. Med., 80: Suppll. IA, 56-61 (1986).
30. Sahloul, M.Z., Kick, R., Ivunovish, P., "Nonsteroidal Anti-inflammatory Drugs and Antihypertensives", Nephron, 56: 345-352 (1990).
31. Faure, L., Vallotton, M.B., "Relation of Renal Prostaglandins to Three Diuretics", Prostaglandins Leukotrienes Med., 14: 313- 318 (1984).
32. Faure, L., Glasson, P., Riondel, A., Vallotton, M.B., "Interaction of Diuretics and Non-steroidal Anti-inflammatory Drugs in Man", Clin. Sci., 64: 407-415 (1983).
33. Fanelli, G.M., Bohn, D.L., Camp, A.E., Shum, W.K., "Inability of İndomethacin to Modify Hydrochlorothiazide Diuresis and Natriuresis by the chimpanzee kidney", J.Pharmacol. Exp. Ther., 213: 596-991 (1980).
34. Davis, A., Day, R.D., Beog, E.J., "Interaction Between NSAID s and Antihypertensives and Diuretics", Aust. N.Z.J. Med., 16: 537-46 (1986).
35. Kirchner, K.A., Brandon, S., Mueller, R.A., Smith, M.S., Bower, J.D., "Mechanism of Attenuated Hydrochlorothiazide Response During Indomethacin Administration", Kidney Int., 31: 1097-1103(1987).
36. Koopmans, P.P., "The Effects of Sulindac and Indomethacin on the Antihypertensive and Diuretic Action of Hydrochlorothiazide in Patients with Mild to Moderate Essential Hypertension" Br. J. Clin. Pharmacol., 31: 417-423 (1986).
37. Davies, J.G., Rawlins, D.C., Busson, H., "Effect of Ibuprofen on Blood Pressure Control by Propranolol and Bendrofluazide", J. Int. Med. Res., 16:173-181 (1988).
38. Koopmans, P.P., "The Influence of Ibuprofen, Diclofenac and Sulindac on the Blood Pressure Lowering Effect of Hydrochlorothiazide", Eur. J. Clin. Pharmacol, 31: 553-57 (1987).
39. Gerber, J.G., LoVerde, M., Byyny, R.L., Nies, A.S., "The Antihypertensive efficacy of Hydrochlorothiazide is not prostacyclin Dependent", Clin. Pharmacol. Ther., 48: 424-30 (1990).
40. Gurwitz, J.H., Everitt, D.E., Monane, M., Glynn, R.J., Choodnovskiy, I., Beaudet, M.P., "The Impact of Ibuprofen on the Efficacy of Anthypertensivce Treatment with Hydrochlorothiazide in Elderly Persons", J. Gerontol. A.Biol. Sci. Med. sci., 51(2): M74-9 (1996).
41. Klassen, D., Goodfriend, T.I., Schuna, A.A., Blood Young, D.Y., Heüedzor, C.A., "Assesment of Blood Pressure During Treatment with Naproxen or Ibuprofen in Hypertensive Patients Treated with Hydrochlorotiazide", J. Clin. Pharmacol., 33(10): 971-8 (1993).
42. Glasson, J.F., Riondel, A. Vallotton, H.B., "Interactions of Diuretics and NSAID s in man", Clin. Sci., 69: 327-36 (1985).
43. Jaegerc, D.D., Boelaert, J.R., Schurgers, R.F., Daneels, R.F., "Do Non-steroidal AntiInflammatory Drugs Influence the Effects of Antihypertensive Drugs", Acta, Clinical Belgica, 41 (3): 189-98 (1986).
44. Baez, M.A., Alvarez, C.R., Weidler, D.J., "Effect of the NSAID s Proxicam or Sulindac on the Antihypertensive Actions of Propranolal and Verapamil", J.Hypertens., 5: 563-6 (1987).
45. Beckman, M.L., Gerber, J.G., "Propranolol Increases Prostacyclin Synthesis in Patients with Essential Hypertension", Hypertension, 12: 532-8 (1988).
46. Smith, S.R., Gibson, R., Bradley, D., Kendull, M.S., "Failure of Indomethacin to Modify adrenoreceptor Blockade", Br. J. Clin., Pharmacol., 15: 267-8 (1983).
47. Salvetti, A., Pedrinelli, R., Alberici, P., Magagna, A., "The Influence of Indomethacin and Sulindac on some Pharmacological Actions of Atenolol in Hypertensive Patients", Br. J. Clin. Pharmacol., 17: 108-11 (1984).
48. Nichimigo, T., Webb, J.G., Daniel, H.B., Oatis, J., "Chronic Treatment with Propranolol Enhances the Synthesis of Prostaglandins", J. Pharmacol. Exp. Ther., 253: 207-213 (1990).
49. Petterson, K., Hansson, G., "Prostacyclin Synthesis in Relation to Sympathoadrenal Activation", Circulation, 84: 38-43 (1991).
50. Twahig, H., "Effect of Aspirin Treatment on the Hypertensive Effect of Clonidin in Rat", Arch. Int. Pharmacol. Ther., 264: 299-304 (1983).
51. Thatte, M.M., "Drug Interaction Between Guanfacin and NSAIDs in Dogs. Pharmacology", 33: 252-300 (1986).
52. Pritchard, M.M., Lyons, D., Webster, J., Petric, J.C., Mc Donald, T.M., "Indomethacin does not Attenuate the Hypotensive Effect of Trandolapril", J. Human Hypertens., 10 (11): 763-7 (1996).
53. Minuz, P., Lech, A., Arosio, E., "Antihypertensive activity of enalapril: Effect of Ibuprofen and Different Salt Intakes", J. Clin. Hypertens., 3: 645-53 (1987).
54. Salvetti, A., "Indomethacin reduces the Antihypertensive Action of Enalapril", Clin. Exp. Hypertens., A. Theory Pract, 9: 559-67 (1987).
55. Omata, K., "Antagonism of Antihypertensive Drug Therapy by NSAID s", Hypertension, 11: 114-6(1988).
56. Oparil, S., "Antihypertensive Effect of Enalapril in Essential Hypertension Role of Prostacyclin", Am. J. Med. Sci., 294: 395-402 (1987).
57. Chelly, S.E., "Effect of Hydralazine of Regional Blood Flow on Conscious Dogs" J. Parmac. Exp. Ther., 39: 564-70 (1986).
58. Dunn, M.J., "Interactions Nonsteroidal Antiinflammatory Drugs and Antihypertensives", JAMA,12: 850-51 (1988).
59. Panzenbeck, M., "Prostaglandins Participate in the Vasodilator Due to Hydralazine in Dog", J. Pharmac. Exp. Ther., 237: 525-29 (1986).
60. Cinquegrani, M.P., Liang, C, "Indomethacin Attenuates the Hypotensive Action of Hydralazine", Clin, Pharmacol. Ther., 39: 564-760 (1986).
61. Jenkin, D.A.S., "The Acute Renal Hemodynamic and Endocrine Response to Felodipine in Normal Man", Eur. J. Clin. Pharmacol., 23: 581-5 (1988).
62. Salvetti, A., "Calcium Antagonists Interaction in Hypertension", Am. J. Nephrol., 6: Suppl.I, 95- 99 (1986).
63. Stockes, G.S., Brooks, P.M., Johnston H. J., Monaghan, J.C., Okoro, E.O., Kelly, D., "The Effects of Sulindac and Diclofenac in Essential Hypertension Controlled by Treatment with Blocker and/or Diuretic", Clin. Exp. Hyper. Therapy and Pract., A-13:l 169-78 (1991).
64. Gurwitz, J.H., Avorn, J., Bohn, R.L., Glynn, R.J., Monane, M., Mogun, H., "Initation of Antihypertensive Treatment during Nonsteroidal Antiinflammatory Drug Therapy", JAMA, 272(10): 781-6 (1994).
65. Jhonson, A.G., Simons, L.A., Friedlander, Y., McCallum, J., "Nonsteroidal Antiinflammatory Drugs and Hypertension in the Elderly", Br.J. Clin. Pharmacol., 35(5): 455-9 (1993).
66. Chrischilles, E.A., Wallace, R.B., "Nonsteroidal Anti-inflammatory Drugs and Blood Pressure in an Elderly Population", J. Gerontol., 48(3): 477-479 (1993).

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ISSN: 1015-3918
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