POTASYUM 2-((4-AMİNO-5-(MORFOLİNOMETİL)-4H-1,2,4-TRİAZOL-3-İL)TİYO) ASETATIN FARMAKOKİNETİĞİ VE POTANSİYEL METABOLİTLERİNİN SIÇANLARDA ARAŞTIRILMASI

Amaç: Bu çalışmanın amacı, sıçanlara intragastrik olarak uygulanan potasyum 2-((4-amino-5-(morfolinometil)-4H-1,2,4-triazol-3-il)tiyo) asetat maddesinin, belirli farmakokinetik parametrelerini ve olası metabolitlerini incelemektir.

Anahtar Kelimeler:

1.2.4-triazol, farmakokinetik, metabolitler

AN INVESTIGATION OF THE PHARMACOKINETICS AND POTENTIAL METABOLITES OF POTASSIUM 2-((4-AMINO-5-(MORFOLINOMETYL)-4H-1,2,4-TRIAZOL-3-YL)THIO) ACETATE ON RATS

Objective: The purpose of this work is to study the designated pharmacokinetic parameters and possible metabolites of the substance potassium 2-((4-amino-5-(morfolinometyl)-4H-1,2,4-triazol-3-yl)thio)acetate by intragastric introduction to rats.

Keywords:

1.2.4-triazole, metabolite, pharmacokinetics,

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1. Gerry, C. J., & Schreiber, S. L. (2018). Chemical Probes And Drug Leads From Advances In Synthetic Planning And Methodology. Nature Reviews Drug Discovery, 17(5), 333.

2. Blumenthal, G. M., Goldberg, K. B., & Pazdur, R. (2017). Drug development, trial design, and endpoints in oncology: adapting to rapidly changing science. Clinical Pharmacology & Therapeutics, 101(5), 572-574.

3. Mohs, R. C., & Greig, N. H. (2017). Drug discovery and development: Role of basic biological research. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 3(4), 651-657.

4. Shcherbyna, R. O. (2014). Pharmacological Activity Analysis Of The 1,2,4-Triazole Derivatives. Pharmaceutical Journal, (4), 145-150.

5. Kumar, R., Yar, M. S., Chaturvedi, S., & Srivastava, A. (2013). Triazole as pharmaceuticals potentials. Inter J Pharm Tech Res, 5(4), 1844-1869.

6. Peyton, L. R., Gallagher, S., & Hashemzadeh, M. (2015). Triazole antifungals: a review. Drugs Today (Barc), 51(12), 705-718.

7. Bushueva, I., Parchenko, V., Shcherbyna, R., Safonov, A., Kaplaushenko, A., Gutyj, B., & Hariv, I. (2017). Tryfuzol-New Original Veterinary Drug. J. Fac. Pharm. Ankara/Ankara Ecz. Fak. Derg, 41(1), 42-49.

8. Shcherbyna, R. O., Danilchenko, D. M., Parchenko, V. V., Panasenko, O. I., Knysh, E. H., Hromyh, N. A., & Lyholat, Y. V. (2017). Studying Of 2-((5-R-4-R-1-4H-1,2,4-triazole-3-yl)thio)acetic Acid Salts Influence On Growth And Progress Of Blackberries (KIOWA Variety) Propagules. Research Journal of Pharmaceutical Biological and Chemical Sciences, 8(3), 975-979.

9. Hulina, Y.S., & Kaplaushenko, A. G. (2018). Synthesis, Physicochemical Properties And Further Transformations In The Series 5-((1H-tetrazol-1-yl)methyl)-4-R-4H-1,2,4-triazol-3-thiols. Biopharmaceutical Journal, 10 (1), 26-30.

10. Samelyuk, Y. G., & Kaplaushenko, A. G. (2014). Synthesis of 3-alkylthio(sulfo)-1,2,4-triazoles, Containing methoxyphenyl substituents at C5atoms, Their antipyretic activity, Propensity to adsorption and acute toxicity. Journal of Chemical and Pharmaceutical Research, 6(5), 1117-1121.

11. Keri, R. S., Patil, S. A., Budagumpi, S., & Nagaraja, B. M. (2015). Triazole: a promising antitubercular agent. Chemical biology & drug design, 86(4), 410-423.

12. Shcherbyna, R., Parchenko, V., Martynyshyn, V., & Hunchak, V. (2018). Evaluation Of Acute And Subacute Toxicity Of Oil Liniment Based On 4-((5-(Decylthio)-4-methyl-4H-1,2,4-triazol-3-yl)methyl)morpholine. J. Fac. Pharm. Ankara/Ankara Ecz. Fak. Derg, 42 (1), 43-52. Retrieved from http://dergipark.gov.tr/jfpanu/issue/42653/514314.

13. Safonov, A. A. (2018). Derivatives of 3-(alkylthio)-5-(thiophen-2-ylmethyl)-4H-1, 2, 4-triazol-4-amines as Anti-fatigue Substances. Indonesian Journal of Pharmacy/Majalah Farmasi Indonesia, 29(3).

14. Küçükgüzel, Ş. G., & Çıkla-Süzgün, P. (2015). Recent advances bioactive 1, 2, 4-triazole-3-thiones. European journal of medicinal chemistry, 97, 830-870.

15. Shcherbyna, R, Vashchyk, Y. (2019). The Research Of 1,2,4-Triazole Derivatives Hepatoprotective Activity Under Tetracycline And Infectious Hepatitis. Journal of Faculty of Pharmacy of Ankara University, 43 (2) , 135-146 . DOI: 10.33483/jfpau.487173

16. Shcherbyna, R. O., & Vashchyk, Y. V. (2018). Histological study of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazole-3-yl)thio)acetate (PKR-173) corrective influence on the chickens liver state in the condition of tetracycline hepatitis. Zaporožskij Medicinskij Žurnal, 3, 404-412.

17. Shcherbyna, R., Parchenko, V., Varynskyi, B., & Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazol-3-yl) thio) acetate substance. Current Issues in Pharmacy and Medical Sciences, 32(1), 5-9.

18. Shcherbyna, R. O. (2017). Synthesis, physical and chemical properties of 2-((4-R-3-(morfolinomethylen)-4H-1,2,4-triazole-5-yl)thio)acetic acid salts. Current Issues in Pharmacy and Medicine: Science and Practice, 10 (1), 4-8.