Ömerül Faruk TAVLI, Ömer HAZMAN, Ahmet BÜYÜKBEN, Fatıma Nur YILMAZ, Berna ÖZBEK ÇELİK, Esra EROĞLU ÖZKAN

İSTANBUL AKTARLARINDA SATILAN HYPERICUM PERFORATUM ÖRNEKLERİNİN FARMAKOGNOZİK AÇIDAN İNCELENMESİ

Amaç: Ülkemizde, halk arasında tedavi amacıyla kullanılan bitkisel droglar genellikle aktarlardan temin edilmektedir. Aktarlarda satılan drogların kalitesi ve güvenilirliği uzun yıllardır tartışılmaktadır. Bu çalışma ile önemli tıbbi bitkilerimizden biri olan ve halk arasında yaygın olarak kullanılan Hypericum perforatum türünün İstanbul aktarlarından satın alınan örnekleri incelenmiştir.

Anahtar Kelimeler:

ağır metal, aktarlar, halk sağlığı, hiperisin, Hypericum perforatum

PHARMACOGNOSTIC RESEARCH ON HYPERICUM PERFORATUM SAMPLES SOLD BY HERBALISTS IN ISTANBUL

Objective: In our country, herbal drugs used for medical purposes by the folk are generally purchased from the herbal stores. The quality and reliability of the plants sold in the herbal stores have been discussed for many years. The present study aims to investigate samples of Hypericum perforatum, which is one of the important medicinal plants and widely used by the folk.

Keywords:

heavy metal, herbalists, hypericin, Hypericum perforatum, public health,

PDF

___

1. Baytop, T. (1999). Türkiye’de Bitkilerle Tedavi, Nobel Tıp Kitabevi, İstanbul, p. 13-62.
2. Baytop, T. (2001). Türk Eczacılık Tarihi, İstanbul Üniversitesi Yayınları, İstanbul, p. 9-29.
3. Eroğlu Özkan, E. (2011). Drosanthe ve Taeniocarpium Seksiyonlarına Ait Bazı Endemik Hypericum Türlerinin Kimyasal Bileşimi ve Biyolojik Aktivite Yönünden İncelenmesi. (Doktora). İstanbul Üniversitesi, İstanbul.
4. Verpoorte, R. (2009). Medicinal Plants: A Renewable Resource for Novel Leads and Drugs In Ramawat, K.G., Sukhadia, M.L. (Eds.), Herbal drugs: Ethnomedicine to Modern Medicine (pp. 1-5). Berlin Heidelberg: Springer-Verlag.
5. Bilia, A.R., Gallori, S., Vincieri, F.F. (2002). St. John's wort and depression: efficacy, safety and tolerability-an update. Life Sciences, 70(26), 3077-3096.
6. Patocka, J. (2003). The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L. Journal of Applied Biomedicine, 1(2), 61-70.
7. Baytop, T. (1980). Farmakognozi ders kitabı, Fatih Yayınevi Matbaası, İstanbul, p. 202.
8. Baytop, T. (2007). Türkçe Bitki Adları Sözlüğü, Türk Dil Kurumu Yayınları, Ankara, p. 152.
9. Hostettmann, K., Wolfender, J.L. (2005). Phytochemistry. In Müller, W.E. (Ed.), St. John's wort and its active principles in depression and anxiety. Frankfurt: Birkhäuser Verlag.
10. Greeson, J.M., Sanford, B., Monti, D.A. (2001). St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology, 153(4), 402-414.
11. Barnes, J., Anderson, L.A., Phillipson, J.D. (2007). St John’s Wort. In Barnes, J., Anderson, L.A., Phillipson, J.D. (Eds.), Herbal Medicines (3. Baskı ed.). London: Pharmaceutical Press.
12. Harrigan, W.F., McCance, M.E. (2014). Laboratory Methods in Microbiology, Academic Press, p. 1-374.
13. Ozkan, E.E., ve ark. (2018). Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum. South African Journal of Botany, 114, 104-110.
14. Radulović, N., ve ark. (2007). Screening of in vitro antimicrobial and antioxidant activity of nine Hypericum species from the Balkans. Food chemistry, 103(1), 15-21.
15. Trovato, A., ve ark. (2001). Anti-inflammatory and analgesic activity of Hypericum empetrifolium Willd. (Guttiferae). Farmaco, 56(5-7), 455-7.
16. Orhan, D.D., Sayın, E. (2016). Quality Control Analysis of the Plants Sold as Senna in Turkey. Clinical and Experimental Health Sciences, 6(3), 116-120.
17. Hazman, Ö., Bozkurt, M.F. (2015). Anti-inflammatory and antioxidative activities of safranal in the reduction of renal dysfunction and damage that occur in diabetic nephropathy. Inflammation, 38(4), 1537-1545.
18. Baltaci, A.K., Mogulkoc, R., Baltaci, S.B. (2019). The role of zinc in the endocrine system. Pakistan journal of pharmaceutical sciences, 32(1).
19. Hordyjewska, A., Popiołek, Ł., Kocot, J. (2014). The many “faces” of copper in medicine and treatment. Biometals, 27(4), 611-621.
20. Li, L., Yang, X. (2018). The essential element manganese, oxidative stress, and metabolic diseases: links and interactions. Oxidative medicine and cellular longevity, 2018.
21. Olechnowicz, J., ve ark. (2018). Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. The Journal of Physiological Sciences, 68(1), 19-31.